Iconeus Functional Ultrasound (fUS) preclinical imaging systems
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Publications on functional ultrasound

For over 10 years, researchers around the world and Iconeus engineers have been developing the technology of functional ultrasound, and using it to gain interesting insights into brain function. Many of their results have been published in high-profile journals such as Nature, Science Translational Medicine and Neuron.

Below you’ll find a comprehensive (but not exhaustive) list of publications covering all aspects of functional ultrasound.
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2011 — 2024

Dynamics of cerebral blood volume during and after middle cerebral artery occlusion in rats – Comparison between ultrafast ultrasound and dynamic susceptibility contrast-enhanced MRI measurements.

Franx BA, Lebrun F, Chin Joe Kie L, Deffieux T, Vivien D, Bonnard T, Dijkhuizen RM; CONTRAST consortium. Dynamics of cerebral blood volume during and after middle cerebral artery occlusion in rats – Comparison between ultrafast ultrasound and dynamic susceptibility contrast-enhanced MRI measurements. J Cereb Blood Flow Metab. 2023 Dec 21:271678X231220698. doi:10.1177/0271678X231220698. Epub ahead of print.

  • Rat
  • Vascular imaging
  • Research article
  • 2023

Dissecting Multiparametric Cerebral Hemodynamics using Integrated Ultrafast Ultrasound and Multispectral Photoacoustic Imaging.

Chen H, Mirg S, Gaddale P, Agrawal S, Li M, Nguyen V, Xu T, Li Q, Liu J, Tu W, Liu X, Drew PJ, Zhang N, Gluckman BJ, Kothapalli SR. Dissecting Multiparametric Cerebral Hemodynamics using Integrated Ultrafast Ultrasound and Multispectral Photoacoustic Imaging. bioRxiv [Preprint]. 2023 Nov 11:2023.11.07.566048. doi: 10.1101/2023.11.07.566048.

  • Rat
  • Vascular imaging
  • Method
  • 2023

Commentary to Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke

Nowak TS Jr, Farr TD. Commentary to Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke. J Cereb Blood Flow Metab. 2024 Jan;44(1):3-5. doi:10.1177/0271678X231207182. Epub 2023 Oct 23.

  • Rat
  • Vascular imaging
  • Research article
  • 2023

Swept-3-D Ultrasound Imaging of the Mouse Brain Using a Continuously Moving 1-D-Array-Part I: Doppler Imaging.

Generowicz BS, Dijkhuizen S, De Zeeuw CI, Koekkoek SKE, Kruizinga P. Swept-3-D Ultrasound Imaging of the Mouse Brain Using a Continuously Moving 1-D-Array-Part I: Doppler Imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2023 Dec;70(12):1714-1725. doi: 10.1109/TUFFC.2023.3318653. Epub 2023 Dec 14.

  • Mouse
  • Vascular imaging
  • Method
  • 2023

Time-lagged Functional Ultrasound for Multi- parametric Cerebral Hemodynamic Imaging.

Liu B, Wang Y, Fomin-Thunemann N, Thunemann M, Kilic K, Devor A, Cheng X, Tan J, Jiang J, Boas DA, Tang J. Time-lagged Functional Ultrasound for Multi-parametric Cerebral Hemodynamic Imaging. IEEE Trans Med Imaging. 2023 Sep 13;PP. doi: 10.1109/TMI.2023.3314734. Epub ahead of print.

  • Mouse
  • Vascular imaging
  • Method
  • 2023

Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma.

Soloukey S, Verhoef L, Generowicz BS, De Zeeuw CI, Koekkoek SKE, Vincent AJPE, Dirven CMF, Harhangi BS, Kruizinga P. Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma. Front Surg. 2023 Jun 5;10:1153605. doi: 10.3389/fsurg.2023.1153605.

  • Human
  • Vascular imaging
  • Method
  • 2023

Microscale acoustic metamaterials as conformal sonotransparent skull prostheses.

Kim G, Rabut C, Ling B, Shapiro M, Daraio C. Microscale acoustic metamaterials as conformal sonotransparent skull prostheses. Res Sq [Preprint]. 2023 May 10:rs.3.rs-2743580. doi: 10.21203/rs.3.rs-2743580/v1.

  • Mouse
  • Resting-state functional connectivity, Functional neuroimaging, Vascular imaging, Neuropharmacology
  • Method
  • 2023

Filler-Enhanced Piezoelectricity of Poly-L-Lactide and Its Use as a Functional Ultrasound-Activated Biomaterial.

Vukomanović M, Gazvoda L, Kurtjak M, Maček-Kržmanc M, Spreitzer M, Tang Q, Wu J, Ye H, Chen X, Mattera M, Puigmartí-Luis J, Pane SV. Filler-Enhanced Piezoelectricity of Poly-L-Lactide and Its Use as a Functional Ultrasound-Activated Biomaterial. Small. 2023 Aug;19(35):e2301981. doi:10.1002/smll.202301981.

  • Resting-state functional connectivity, Functional neuroimaging, Vascular imaging
  • Method
  • 2023

Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke.

Brunner C, Denis NL, Gertz K, Grillet M, Montaldo G, Endres M, Urban A. Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke. J Cereb Blood Flow Metab. 2024 Jan;44(1):6-18. doi: 10.1177/0271678X231191600.

  • Rat
  • Vascular imaging
  • Research article
  • 2023

In vivo whole brain microvascular imaging in mice using transcranial 3D Ultrasound Localization Microscopy.

Demeulenaere O, Bertolo A, Pezet S, Ialy-Radio N, Osmanski B, Papadacci C, Tanter M, Deffieux T, Pernot M. In vivo whole brain microvascular imaging in mice using transcranial 3D Ultrasound Localization Microscopy. EBioMedicine. 2022 May;79:103995. http://doi: 10.1016/j.ebiom.2022.103995.

  • Mouse
  • Vascular imaging
  • Research article
  • 2022
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