Webinar: Insights into stroke and neurovascular diseases using in vivo imaging

Early vascular dysfunction is increasingly recognized as the underlying cause of many neurological diseases. The development of drugs targeting vascular damage at its earliest stages could therefore pave the road towards the treatment of neurological disorders. However, to be effective, this therapeutic approach will require the identification of early markers of vascular injury.

In the first part of the webinar, Professor Lebrin, from Leiden University Medical Center, will discuss his research on ultrasound markers of early vascular dysfunction in cerebral hereditary angiopathies (CHA). Blood vessels from CHA exhibit the salient features of other neurological diseases, and so provide tractable preclinical models for research and defined patient groups for trials. Professor Lebrin will explain how his team expects to identify early cerebrovascular markers that could ultimately be translated to the clinic for monitoring of disease progression and drug action.

In the second part of the webinar, Professor Vivien, from the University of Caen Normandy, will present therapeutic approaches for ischemic stroke for quickly restoring cerebral blood flow, including treatment with tissue-type plasminogen activator and endovascular thrombectomy. Professor Vivien’s will explain how his research aims to better understand the spatiotemporal evolution of functional and molecular events that occur during and following stroke, using a combination of in vivo fUS imaging and high-resolution MRI.