Iconeus One

Iconeus One is today the first and only fully-featured commercial acquisition system for pre-clinical functional ultrasound (fUS) imaging of brain activity and vasculature, designed and implemented by the inventors of fUS imaging for simple plug-and-play operation. 


With Iconeus One you can measure neuronal activation and connectivity through the neurovascular coupling – with higher sensitivity and resolution than with BOLD-based fMRI – in behaving or in anesthetized animals. 
 
Iconeus One draws on our patented MPW™ (multi-plane-wave) ultrasound and fUS technology. Its ultra-fast imaging frame rate, together with our highly-optimized proprietary acquisition hardware leads to ultra-high sensitivity and resolution, which enables to directly measure subtle variations in the blood volume of individual voxels in the brain.

Iconeus One - neuronal activation and connectivity
Iconeus One: designed, developed and produced in Paris, France

3D fUS volumes of the rodent brain

Iconeus One maps 3D brain activation and intrinsic connectivity patterns with ultra-high sensitivity and resolution. For more information, read our newsletter on the state-of-the art in multidimensional fUS imaging.

System specifications

  • Real time engine: MPW™ (multi-plane-wave) technology
  • Spatial resolution: 100 × 100 × 400 μm at 15 MHz
  • Temporal resolution: Down to 10 ms
  • Awake kits: Rat, mouse and primate 
  • Robotic station for head-fixed animals: 4-axis high speed motorized platform
  • Capacity: 10 TB, >25 Tflops
  • Dimensions: l: 809,5 × L: 971 × D: 971 × H: 650 mm

 

Real time engine
Transcranial imaging of the functional connectivity in the mouse brain

System details

Ease of use

  • No need for expertise in imaging technology 
  • "Plug and scan" 
  • User-friendly software with presets for rapid acquisition and processing 
  • Integrated 3D mouse brain atlas 
  • Compatible with other imaging modalities (EEG, optogenetics, etc.) 
  • Compact, wheeled imager 
  • On-site installation and support 

Awake imaging

  • Unique microprobe design 
  • Awake, freely moving, resting-state and asleep conditions 
  • Rats, mice, birds, primates, ferrets, marmosets, guinea pigs, reptiles

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Iconeus One in your lab

Applications

Fundamental neuroscience research

Multimodal insight
Perform unbiased whole-brain imaging of brain circuits in awake, active animals, study cerebral blood volume variation or neurovascular coupling in genetic models, integrate easily with electrophysiology, optogenetics, guided injections or in any way you envision. Create your very own experimental paradigm with the power of Iconeus technology at its core in a matter of days rather than months and win the race to discover the next big thing. Iconeus now works with some of the finest labs in the world to help implement their vision.

Pharmacology and drug discovery

Better than BOLD
Unsatisfied with inconclusive behavioral results or complicated and expensive fMRI studies? Iconeus functional ultrasound neuroimaging is the readout you need for reliable results in your drug discovery process. Study, in 4D, real-time functional activation and connectivity between brain structures through neurovascular coupling, including easy-to-perform transcranial imaging in mice models. Our dedicated software suite makes it simple to perform standardized and reliable measurements and can easily be integrated in your own workflow. Iconeus is trusted by our big pharma customers around the world to deliver the tools they need.

Stroke and neurovascular research

Time is brain
See a stroke unfolding before your eyes, follow occlusion, reperfusion and early recanalization dynamics right when they happen. Map injured brain territories and quantify longitudinally the efficacy of new treatments. With Iconeus technology, you can better evaluate the quality of your stroke model and easily triage animals based on early images. Turn your model variability into a strength, gain time and engage in precision biology.

Technology

Our technology leverages more than 20 years of innovations in brain ultrasound imaging. Its history begins at the Langevin Institute of ESPCI Paris, where the research team led by Prof. Mickael Tanter (INSERM, ESPCI Paris, CNRS) pioneered functional ultrasound neuroimaging and produced other major breakthroughs in biomedical echography.

Since 2011, we have been working intensively with neuroscientists to carefully adapt our technology to their specific needs.

Our technology is protected by a strong patent portfolio to ensure the best quality and experience for our customers.

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Ultra-high sensitivity angiography
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