We’re Iconeus – a Paris-based company, founded by the inventors of functional ultrasound, who have invented an easy-to-use functional ultrasound system for imaging cerebral blood flow and microvasculature. Its unique combination of sensitivity, speed and high resolution has enabled it to lead the field in preclinical studies on awake animals, and it is now being proposed for applications in clinical research too.
Iconeus One is a breakthrough in brain research, offering through the same revolutionary technology both high-end neuroimaging and outstanding hemodynamic mapping. As well as allowing brain activity in mice, rats and other small animals to be imaged quickly and easily, it is now starting to be used for clinical research in humans too. Iconeus One is:
Functional ultrasound uses multi-plane-wave ultrasound to
generate 2D images of blood flows across the brain in a
matter of seconds. This makes it possible to follow changes
in neuronal activation over time (thanks to the neurovascular
coupling), or to generate 3D images of the entire brain
As well as allowing mobile animals to be imaged using our compact probes, functional ultrasound provides far greater spatial and temporal coverage than the restricted ‘snapshots’ possible with conventional ultrasound. It’s also inherently sensitive, allowing it to spot small changes in neuronal activation much more readily than fMRI.
Hear from our founder Mickael Tanter about the potential of functional ultrasound in this two-minute video.
Functional ultrasound has many applications in neuroscience, including in fundamental brain research, drug development, and investigations into neurodegenerative disorders and stroke (see our full list of publications for examples). But across all of these areas, there are four main ways in which fUS can be used:
In the years since Iconeus was founded, we’ve developed collaborations with over 30 companies and organizations around the world, who are keen to see what functional ultrasound could offer them (and we’re happy to say that all of them have loved it).
We’ve assembled a talented team here at our facilities in
Paris: experts in neuroscience, ultrasound physics and software
engineering work side-by-side to develop new product features, and
to fine-tune the technology for emerging applications.
So whatever you’d like to talk about – from the finer points of determining resting-state functional connectivity to the approximate price for a tailored Iconeus One system – there’s bound to be someone who can help (and they’re probably sitting next to us!).