Iconeus One system

Iconeus One is the only full-featured acquisition system for pre-clinical functional ultrasound imaging of brain activity (fUS) and vasculature imaging. This breakthrough modality is based on the measurement of blood volume with an unprecedented ultra-high sensitivity.
 
With Iconeus One you can measure neuronal activation and connectivity – with higher sensitivity and resolution than with BOLD-based fMRI – in behaving or anesthetized animals. 
 
Iconeus One draws on our patented multi-plane-wave™ ultrasound technology. Its ultra-fast frame rate allows the user to image neuronal activity through neurovascular coupling, while its ultra-high sensitivity makes it possible to directly measure subtle variations in the blood volume of individual voxels in the brain.

System specifications

  • Real time engine: Multi-plane-wave technology
  • Spatial resolution: 100 × 100 × 400 μm at 15 MHz
  • Temporal resolution: Down to 10 ms
  • Awake kits: Rat, mouse and primate 
  • Robotic station for head-fixed animals: 4-axis high speed motorized platform
  • Capacity: 10 TB, >25 Tflops
  • Dimensions: l: 809,5 × L: 971 × D: 971 
Highlight functionally connected brain regions

Ease of use

  • No need for expertise in imaging technology 
  • "Plug and scan" 
  • User-friendly software with presets for rapid acquisition and processing 
  • Integrated 3D mouse brain atlas 
  • Compatible with other imaging modalities (EEG, optogenetics, etc.) 
  • Compact, wheeled imager 
  • On-site installation and support 

Awake imaging

  • Unique microprobe design 
  • Awake, freely moving, resting-state and asleep conditions 
  • Rats, mice, birds, primates, ferrets, guinea pigs

Iconeus One in your lab.

Applications

Pharmacology & drug discovery

Better than BOLD
Unsatisfied with inconclusive behavioral results or complicated and expensive fMRI studies ? Iconeus functional ultrasound neuroimaging is the readout you need for reliable results in your drug discovery process. Study in 4D real time functional activation and connectivity between brain structures through the neurovascular coupling, including easy transcranial imaging in mice models. Our dedicated software suite makes it simple to perform standardized and reliable measurements and can easily be integrated in your own workflow. Iconeus is trusted by a big pharma company partners to deliver the tools they need.

Fundamental neuroscience research

Multimodal insight
Perform unbiased whole-brain imaging of brain circuits in awake, active animals, study cerebral blood volume variation or neurovascular coupling in genetic models,  integrate easily with electrophysiology, optogenetics, guided injections or else, as you envision. Create your very own experimental paradigm with the power of Iconeus technology at its core in a matter of days rather than months and win the race to the next discovery! Iconeus works now with some of the finest labs in academia worldwide to help their vision unfold.

Stroke and neurovascular research

Time is brain
See a stroke unfolding before your eyes, follow occlusion, reperfusion and early recanalization dynamics right when they happen. Map injured brain territories and quantify longitudinally the efficacy of new treatments. With Iconeus technology, you can better evaluate the quality of your stroke model and easily triage animals based on early images. Turn your model variability into a strength, gain time and engage in precision biology.

For preclinical research, the portability and high versatility of our technology enables the study of brain activity at unprecedented scales and in a large variety of subject states:

  • awake,
  • freely moving,
  • resting-state
  • and asleep conditions.

Our technology leverages more than 20 years of innovations in brain ultrasound imaging. Its history begins at the Langevin Institute (Paris, France), where the research team led by Prof. Mickael Tanter (Inserm, ESPCI Paris, CNRS) pioneered functional ultrasound neuroimaging and produced other major breakthroughs in biomedical echography.

Since 2011, we have been working intensively with neuroscientists to finely adapt our technology to their specific needs.

Our technology is protected by a strong patent portfolio to ensure the best quality and experience for our customers.

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