Functional ultrasound for high-resolution whole-brain imaging of awake animals

We’re Iconeus – a Paris-based company who have invented and commercialized an easy-to-use functional ultrasound system for imaging changes in cerebral blood volumes. It’s sensitive, fast, high-resolution, and it can be used on moving animals.

Whole-brain functional ultrasound activation map acquired on Iconeus One following pulsed visual stimulation in an anesthetized mouse. Regions with significant activation (color scale) are superimposed on the pre-acquired brain vasculature (grey scale), showing increased blood flows in the visual cortices, lateral geniculate nuclei and superior colliculi.
Whole-brain functional ultrasound activation map acquired on Iconeus One following pulsed visual stimulation in an anesthetized mouse. Regions with significant activation (color scale) are superimposed on the pre-acquired brain vasculature (grey scale), showing increased blood flows in the visual cortices, lateral geniculate nuclei and superior colliculi.

Iconeus One: Plug-and-play functional ultrasound imaging

Iconeus One is a breakthrough in preclinical research – a system that allows brain activity in mice, rats and other small animals to be imaged quickly and easily. Iconeus One is:

How does fUS neuroimaging work?

Functional ultrasound uses multi-plane-wave ultrasound to generate 2D images of blood flows across the brain in a matter of seconds. This makes it possible to follow changes in neuronal activation over time (thanks to the neurovascular coupling), or to generate 3D images of the entire brain vasculature.

As well as allowing mobile animals to be imaged using our compact probes, functional ultrasound provides far greater spatial and temporal coverage than the restricted ‘snapshots’ possible with conventional ultrasound. It’s also inherently sensitive, allowing it to spot small changes in neuronal activation much more readily than fMRI.

Play Video Hear from our founder Mickael Tanter about the potential of functional ultrasound in this two-minute video.
Play Video

Hear from our founder Mickael Tanter about the potential of functional ultrasound in this two-minute video.

Applications of fUS brain imaging

Functional ultrasound has many applications in neuroscience, including in fundamental brain research, drug development, and investigations into neurodegenerative disorders and stroke (see our full list of publications for examples). But across all of these areas, there are four main ways in which fUS can be used: ​

Testimonials

It’s fair to say that our customers are pretty impressed by Iconeus One!

Our customers

In the years since Iconeus was founded, we’ve developed collaborations with over 20 companies and organizations around the world, who are keen to see what functional ultrasound could offer them (and we’re happy to say that all of them have loved it).

Our latest news & events

Iconeus’ 3D ULM technology used to image the mouse brain with microscale resolution
A paper authored by Iconeus staff demonstrates that the mouse brain microvasculature can be imaged in vivo directly through the intact skull using our 3D ULM technology.
Read More
Join us at the ISMRM–ESMRMB conference in London
In early May 2022, we’ll be heading to London to talk to users of MR systems, to help us understand the challenges they face, and how fUS might be able to help.
Read More
Iconeus welcomes two new staff in project management and marketing communication
We’re delighted to welcome Ghada Moukalled and Léa Kianpour, who will be taking on the new roles of Project Manager and Communication Project Manager, respectively.
Read More

Have a question about fUS imaging?

We’ve assembled a talented team here at our facilities in Paris: experts in neuroscience, ultrasound physics and software engineering work side-by-side to develop new product features, and to fine-tune the technology for emerging applications.

So whatever you’d like to talk about – from the finer points of determining resting-state functional connectivity to the approximate price for a tailored Iconeus One system – there’s bound to be someone who can help (and they’re probably sitting next to us!).