On-demand webinars

The applications of functional ultrasound are many and varied, so we’re often presenting webinars explaining the details to new audiences. Get involved by watching one of our on-demand webinars below.

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Microvascular & functional ultrasound imaging: Insights into stroke and neurovascular diseases

Description
Professors Franck Lebrin (Leiden University Medical Center) and Professor Denis Vivien (University of Caen Normandy) discuss in vivo molecular and functional imaging, including ultrasound-based markers, and their application to the study and treatment of neurological disorders, including cerebral hereditary angiopathies and ischemic stroke.

Highlights
  • An overview of the organization and functions of the brain vasculature
  • An introduction to cerebral hereditary angiopathies
  • The correlation between fUS data, imaging, and vascular dysfunction
  • The relevance of experimental stroke models in rodents for clinical translation
  • How MRI can be used to reveal inflammatory processes
  • The value of fUS imaging in the field of stroke
  • The future of stroke diagnosis and prognosis
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Functional ultrasound neuroimaging
in awake & behaving non-human primates

Description
Dr Pierre Pouget (Paris Brain and Spine Institute) and Dr Serge Picaud (INSERM Vision Institute) provide an overview of fUS imaging, and how it can be used to study the brain in behaving non-human primates.

Highlights
  • An introduction to fUS brain imaging
  • Single trial detection of changes in cerebral blood volume in non-human primates
  • The simultaneous use of fUS and electrophysiology for macroscopic, mesoscopic, and microscopic measurement of brain activity
  • An introduction to visual restoration strategies
  • The use of fUS to measure and map visual cortex activity including retinotopic maps and ocular dominance columns
  • Clinical trials using retinal prostheses and optogenetic therapy to restore vision
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Functional ultrasound (fUS) imaging
in pain and pharmacology research

Description
Dr Sophie Pezet (Physics for Medicine Paris) and Dr Benjamin Vidal (Theranexus) discuss the methodology, applications and new possibilities enabled by fUS imaging, with a focus on chronic pain and neuropharmacology research.

Highlights
  • An introduction to the methodology of fUS and ‘pharmaco-fUS’ experiments
  • How fUS compares to other neuroimaging techniques: sensitivity, versatility and current challenges
  • Feasibility of fUS in anaesthetized or awake animals, and how it compares to other in vivo neuroimaging methods
  • The information fUS provides to address neurobiological questions and to understand effects of drugs
  • How ‘pharmaco-fUS’ differs from other fUS experiments (resting state or sensory stimulation/task-based paradigms)

Functional ultrasound (fUS) imaging
in the brain of awake behaving mice

Description
Dr Zsolt Lenkei (INSERM Institute of Psychiatry and Neurosciences) and Dr Artem Shatilo (Charles River) discuss how fUS imaging in awake head-fixed mice can help advance basic neuroscience and neurovascular research, as well as preclinical drug discovery.

Highlights
  • An introduction to fUS methodology
  • How translational fUS neuroimaging helps to advance basic neuroscience research and preclinical drug discovery
  • The main advantages and limitations of using fUS compared to other techniques such as BOLD-based fMRI
  • The benefits of imaging in awake, head-restrained but otherwise freely moving mice
  • How to achieve imaging of functional activation, connectivity and pharmacologically-induced changes in awake and behaving mice
  • How to combine fUS imaging with behavioral observation