Publications on functional ultrasound

For over 10 years, researchers around the world and Iconeus engineers have been developing the technology of functional ultrasound, and using it to gain interesting insights into brain function. Many of their results have been published in high-profile journals such as Nature, Science Translational Medicine and Neuron.

Below you’ll find a comprehensive (but not exhaustive) list of publications covering all aspects of functional ultrasound.

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Model

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Application

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Type

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Year
Research articlePublished in 2025

Functional Ultrasound Imaging of Cocaine Induced Brain-Wide Neurovascular Response

Shaoyuan Yan, Nan Huang, Yusheng Tong, Yousheng Shu, Qiumin Le, Dean Ta, Kailiang Xu

Application:
Neuropharmacology
Model:
Rat
Research articlePublished in 2025

Ketamine-induced static and dynamic functional connectivity changes are modulated byopioid receptors and biological sex in rats

Valeria Grasso, Joseph Tennyson, Raag D. Airan & Tommaso Di Ianni

Application:
Functional neuroimaging
Model:
Rat
MethodPublished in 2024

Sex dependence of opioid-mediated responses to subanesthetic ketamine in rats

Tommaso Di Ianni, Sedona N. Ewbank, Marjorie R. Levinstein, Matine M. Azadian, Reece C. Budinich,Michael Michaelides & Raag D. Airan

Application:
Neuropharmacology
Model:
Rat
Research articlePublished in 2025

Distributed Activity in the Medial Frontal Cortex Predicts Self-Initiated Action

Julien Claron, Matthieu Blons, Alexandre Dizeux, Thomas Deffieux, Mickael Tanter, Béatrice Berthon,Pierre Pouget

Application:
Functional neuroimaging
Model:
Non-Human Primate
Research articlePublished in 2025

A piece of evidence for pathogenesis of cerebral small vessel disease caused by blood-brainbarrier dysfunction — Based on the STRIVE-2 imaging features

Yi Yang, Huide Ma, Bowei Liu, Rong Wu, Sujuan Sun, Xia Li, Yu He, Shumin Wang

Application:
Functional neuroimaging
Model:
Rat
Research articlePublished in 2025

Functional Ultrasound Imaging Reveals Activation Properties of Clinical Spinal Cord Stimulation Therapy Programming

Lim K, Slee SJ, Kibler A, Falowski S, Amirdelfan K

Application:
Functional neuroimaging
Model:
Ovine
Research articlePublished in 2025

Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral bloodflow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain

Siva Sai Chandragiri, Adam Nyul-Toth, Sharon Negri, Roland Patai, Rafal Gulej, Boglarka Csik, SantnyShanmugarama, Kiana Vali Kordestan, Mark Nagykaldi, Peter Mukli, Anna Ungvari, Andriy Yabluchanskiy,Zoltan Ungvari, Stefano Tarantini & Anna Csiszar

Application:
Vascular imaging
Model:
Mouse
Research articlePublished in 2025

Super-Resolution Ultrasound Reveals Cerebrovascular Impairment in a Mouse Model ofAlzheimer’s Disease

Matthew R. Lowerison, Nathiya Vaithiyalingam Chandra Sekaran, Zhijie Dong, Xi Chen, Qi You, Daniel A.Llano and Pengfei Song

Application:
ULM
Model:
Mouse
Research articlePublished in 2025

Spinal ultrasound imaging implied the vascular dynamics in chronic and acute pain

Yingzhuo Ding, Chunxia Yu, Qingqing Chi, Mengjiao Deng, Dongxia Duan, Jinbao Wei, Yufei Xi, Qin Li, Le Ma

Application:
Functional neuroimaging
Model:
Rat
MethodPublished in 2025

PhysiofUS : a tissue-motion based method for heart and breathing rate assessment in neurofunctional ultrasound imaging

Nicolas Zucker, Samuel Le Meur-Diebolt, Felipe Cybis Pereira, Jerome Baranger, Isabella Hurvitz,  Charlie Demené, Bruno Osmanski,  Nathalie Ialy-Radio, Valérie Biran, Olivier Baud, Sophie Pezet, Thomas Deffieux, Mickael Tanter

Application:
Functional neuroimaging
Model:
Mouse
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