Functional ultrasound (fUS) imaging of brain activation and connectivity emerged as a breakthrough preclinical imaging modality during the last decade. Providing significantly higher sensitivity and spatiotemporal resolution than the gold-standard BOLD-based fMRI approach, with greater operating simplicity and affordability, and providing the option of operating in awake and behaving animals to avoid the bias of anesthesia, fUS clearly opens broad new perspectives both in academic research and drug development. In early 2020, the first commercial fUS system, Iconeus One, created by the inventors of fUS, provided an opportunity for everyone to access this technology through an easy-to-use integrated device. Originally limited to imaging a single 2D plane, recent years have witnessed important technological breakthroughs extending fUS imaging to new dimensions. As two different technological solutions are currently proposed for the acquisition of 3D and 4D fUS data, each with its own advantages and drawbacks, we invited two eminent fUS experts from academia and industry, Prof. Mickael Tanter, the inventor and pioneer of 2D, 3D and 4D fUS technology, and Dr. Bruno Osmanski, the CTO of Iconeus, to share their views on the current state of multidimensional fUS.
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Towards multidimensional fUS imaging
May 18, 2020